Peptide Atlas · Buffer system

Acetate buffer

Buffers regulate pH shifts in protein formulations and can also stabilize or destabilize the protein; they influence perceived pain on injection.

established

provisional
2 citations
0 discussions
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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- established
  Claim: Review: role of buffers in protein formulations standing
- resolved
Role of Buffers in Protein Formulations.
Zbacnik TJ, Holcomb RE, Katayama DS, Murphy BM, Payne RW, Coccaro RC, Evans GJ, Matsuura JE, Henry CS, Manning MC
pmid 27894967
- preclinical
  Claim: Acetate and histidine buffers during freeze-drying standing
- resolved
A novel histidine-acetate buffer for freeze-dried monoclonal antibody formulations.
Lv JY, Gao H, Xie HF, Jin MJ, Di B, Xu J, Fang WJ
pmid 41308842

A claim's standing is its latest row in an append-only history; a tombstone names the later evidence and the reason. The Graveyard and the Resurrection Yard.

Negative findings

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