Despite most early peptide research using trifluoroacetate salts, the great majority of therapeutic peptides are marketed as hydrochloride or acetate salts.
established — replicated in humans, or settled by a regulator
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Despite most early peptide research using trifluoroacetate salts, the great majority of therapeutic peptides are marketed as hydrochloride or acetate salts. · pmid:40365687
Mechanism
Acetate, hydrochloride and trifluoroacetate salts of the same antimicrobial peptides differed in activity and toxicity, without a consistent pattern across peptides. · pmid:29307075
Proportion of the 2 claims about Acetate salt standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Acetate salt yet.
Dose evidence, rung by rung
A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
Impact of counterion and salt form on the properties of long-acting injectable peptide hydrogels for drug delivery. · pmid 40365687 · 2025
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
Counter-ion effect on antistaphylococcal activity and cytotoxicity of selected antimicrobial peptides. · pmid 29307075 · 2018
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.