BPC-157

Summary

BPC 157 is a 15-amino-acid partial sequence of body protection compound, a protein discovered in and isolated from human gastric juice. · pmid:21030672

Mechanism

In rat tendon fibroblasts it accelerated outgrowth and migration and raised FAK and paxillin phosphorylation without directly changing proliferation. · pmid:21030672

A review by its originating group relates its healing effects across many injury models to an interaction with the nitric oxide system. · pmid:23755725

History

In rats it protected the stomach and duodenum in restraint-stress, cysteamine and ethanol lesion models where comparison drugs did not, an effect the authors related to endothelial protection. · pmid:7904712

Identity

PubChem CID 9941957: Bpc-157, C62H98N16O22, 1419.5 g/mol. · pubchem:9941957

CAS registry number 137525-51-0. · pubchem:9941957

Where the evidence actually sits

Proportion of the 3 claims about BPC-157 standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

3 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for BPC-157 yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier

   nothing resolved on this rung

3. Observational evidence · resolved human data at the emerging tier: thin, or contested

   nothing resolved on this rung

4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work
   • The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. · pmid 21030672 · 2011
   • Stable gastric pentadecapeptide BPC 157-NO-system relation. · pmid 23755725 · 2014
   • The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides. · pmid 7904712 · 1994

3 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.