Calcium pantothenate (Vitamin B5)

Mechanism

Pantothenic acid (vitamin B5) is the starting material from which coenzyme A is assembled in five steps. · pmid:15893380

Pantothenate kinase, the first enzyme of coenzyme A synthesis, controls how much coenzyme A a cell makes: pantothenate was the most abundant pathway component in normal cells, and raising the enzyme's expression increased cellular coenzyme A 13-fold. · pmid:10625688

Identity

PubChem CID 443753: Calcium Pantothenate, C18H32CaN2O10, 476.5 g/mol. · pubchem:443753

CAS registry number 137-08-6. · pubchem:443753

IUPAC name: calcium bis(3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoate). · pubchem:443753

Where the evidence actually sits

Proportion of the 2 claims about Calcium pantothenate (Vitamin B5) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Calcium pantothenate (Vitamin B5) yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier
   • Coenzyme A: back in action. · pmid 15893380 · 2005
3. Observational evidence · resolved human data at the emerging tier: thin, or contested

   nothing resolved on this rung

4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work
   • Pantothenate kinase regulation of the intracellular concentration of coenzyme A. · pmid 10625688 · 2000

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.