Cardiogen

Mechanism

A review of vasoprotective peptides reports that the tetrapeptide AEDR (Ala-Glu-Asp-Arg) regulates the synthesis of molecules involved in inflammaging and the senescence-associated secretory phenotype of cardiovascular cells. · pmid:36611900

Identity

PubChem CID 11583989: H-Ala-Glu-Asp-Arg-OH, C18H31N7O9, 489.5 g/mol. · pubchem:11583989

CAS registry number 857267-11-9. · pubchem:11583989

IUPAC name: (4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-[[(1S)-1-carboxy-4-(diaminomethylideneamino)butyl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid. · pubchem:11583989

Where the evidence actually sits

Proportion of the 1 claim about Cardiogen standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

1 resolved citation, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Cardiogen yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier

   nothing resolved on this rung

3. Observational evidence · resolved human data at the emerging tier: thin, or contested

   nothing resolved on this rung

4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work
   • Senescence-Associated Secretory Phenotype of Cardiovascular System Cells and Inflammaging: Perspectives of Peptide Regulation. · pmid 36611900 · 2022

1 resolved citation, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.