Coenzyme A (CoA)

Summary

Coenzyme A is an essential cofactor present in all cells, central to the metabolism of carboxylic acids including short- and long-chain fatty acids; it is assembled in five steps from pantothenic acid (vitamin B5). · pmid:15893380

Mechanism

Mutations in pantothenate kinase, the enzyme that begins coenzyme A synthesis, are associated with a human neurodegenerative disorder, and the bacterial pathway is studied as an antibacterial drug target. · pmid:15893380

Identity

PubChem CID 87642: Coenzyme A, C21H36N7O16P3S, 767.5 g/mol. · pubchem:87642

CAS registry number 85-61-0. · pubchem:87642

IUPAC name: [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] hydrogen phosphate. · pubchem:87642

Where the evidence actually sits

Proportion of the 1 claim about Coenzyme A (CoA) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

1 resolved citation, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Coenzyme A (CoA) yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier
   • Coenzyme A: back in action. · pmid 15893380 · 2005
3. Observational evidence · resolved human data at the emerging tier: thin, or contested

   nothing resolved on this rung

4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work

   nothing resolved on this rung

1 resolved citation, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.