Davunetide

Summary

Davunetide (NAP, AL-108) is an intranasal peptide that stabilized microtubules and reduced tau phosphorylation in preclinical studies; in a 52-week phase 2/3 trial in 313 people with progressive supranuclear palsy it did not differ from placebo on either primary measure. · pmid:24873720

In a 12-week trial in 63 people with schizophrenia, davunetide did not significantly change cognition against placebo but improved a measure of functional capacity. · pmid:22169248

Identity

PubChem CID 9832404: Davunetide, C36H60N10O12, 824.9 g/mol. · pubchem:9832404

CAS registry number 211439-12-2. · pubchem:9832404

IUPAC name: (2S)-5-amino-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoic acid. · pubchem:9832404

Where the evidence actually sits

Proportion of the 2 claims about Davunetide standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

Primary structure, N-terminus to C-terminus: 8 residues as the record states them. No 2D or 3D depiction is on record; none is guessed.

Source pubchem:9832404, fetched not recalled. Side-chain classes are the textbook classes of the standard residues.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier
   • Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial. · pmid 24873720 · 2014
3. Observational evidence · resolved human data at the emerging tier: thin, or contested
   • Effect of the neuroprotective peptide davunetide (AL-108) on cognition and functional capacity in schizophrenia. · pmid 22169248 · 2012
4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work

   nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.