Dimethyl sulfoxide (DMSO) has been the cryoprotectant of choice for most animal cell systems since the early history of cryopreservation, used in many thousands of cell transplants.
established — replicated in humans, or settled by a regulator
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Dimethyl sulfoxide (DMSO) has been the cryoprotectant of choice for most animal cell systems since the early history of cryopreservation, used in many thousands of cell transplants. · pmid:32342730
Dimethyl sulfoxide (DMSO) has been the cryoprotectant of choice for most animal cell systems since the early days of cryopreservation, used for stored bone marrow and blood cells in many thousands of transplants, while its toxicity in patients remains debated. · pmid:32342730
History
Its effects on cell biology and apparent toxicity in patients remain debated, driving a search for less cytotoxic cryoprotectants. · pmid:32342730
Proportion of the 2 claims about Dimethyl sulfoxide standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Dimethyl sulfoxide yet.
Dose evidence, rung by rung
A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
Dimethyl sulfoxide: a central player since the dawn of cryobiology, is efficacy balanced by toxicity? · pmid 32342730 · 2020
Dimethyl sulfoxide: a central player since the dawn of cryobiology, is efficacy balanced by toxicity? · pmid 32342730 · 2020
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
nothing resolved on this rung
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.