DSIP

Summary

Delta sleep-inducing peptide (DSIP) is a nonapeptide of molecular weight 849, reported to induce mainly delta sleep in rabbits, rats, mice and humans. · pmid:6145137

History

Its isolation and characterization ran from 1963 to 1977; a 1986 review noted that its physiological functions and mechanism of action remained to be established. · pmid:3550726

Identity

PubChem CID 68816: Delta Sleep-Inducing Peptide, C35H48N10O15, 848.8 g/mol. · pubchem:68816

CAS registry number 62568-57-4. · pubchem:68816

IUPAC name: (2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]acetyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]pentanedioic acid. · pubchem:68816

Where the evidence actually sits

Proportion of the 2 claims about DSIP standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for DSIP yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier

   nothing resolved on this rung

3. Observational evidence · resolved human data at the emerging tier: thin, or contested
   • Delta-sleep-inducing peptide (DSIP): a review. · pmid 6145137 · 1984
4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work
   • Delta-sleep-inducing peptide (DSIP): an update. · pmid 3550726 · 1986

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.