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Peptide Atlas · Mineral

Ferric carboxymaltose

In the AFFIRM-AHF trial of 1,108 patients stabilised after acute heart failure with iron deficiency, intravenous ferric carboxymaltose lowered total heart failure hospitalisations against placebo (rate ratio 0.74) without changing cardiovascular death.

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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

    • established
      Claim: Ferric carboxymaltose causes far more hypophosphatemia than iron isomaltoside (two RCTs) standing
    • resolved

    Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia: Two Randomized Clinical Trials.

    Wolf M, Rubin J, Achebe M, Econs MJ, Peacock M, Imel EA, Thomsen LL, Carpenter TO, Weber T, Brandenburg V, Zoller H

    pmid 32016310

    • established
      Claim: Ferric carboxymaltose reduced heart failure hospitalisations after acute heart failure (AFFIRM-AHF) standing
    • resolved

    Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial.

    Ponikowski P, Kirwan BA, Anker SD, McDonagh T, Dorobantu M, Drozdz J, Fabien V, Filippatos G, Göhring UM, Keren A, Khintibidze I, Kragten H, Martinez FA, Metra M, Milicic D, Nicolau JC, Ohlsson M, Parkhomenko A, Pascual-Figal DA, Ruschitzka F, Sim D, Skouri H, van der Meer P, Lewis BS, Comin-Colet J, von Haehling S, Cohen-Solal A, Danchin N, Doehner W, Dargie HJ, Motro M, Butler J, Friede T, Jensen KH, Pocock S, Jankowska EA, AFFIRM-AHF investigators

    pmid 33197395

A claim's standing is its latest row in an append-only history; a tombstone names the later evidence and the reason. The Graveyard and the Resurrection Yard.

Negative findings

failure is information

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