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Peptide Atlas · Mineral

Ferric derisomaltose (iron isomaltoside 1000)

In the IRONMAN trial of 1,137 patients with heart failure and iron deficiency, intravenous ferric derisomaltose lowered recurrent heart failure admissions and cardiovascular death against usual care (rate ratio 0.82), short of statistical significance except in a pre-specified COVID-19 sensitivity analysis.

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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

    • established
      Claim: Iron isomaltoside causes much less hypophosphatemia than ferric carboxymaltose (two RCTs) standing
    • resolved

    Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia: Two Randomized Clinical Trials.

    Wolf M, Rubin J, Achebe M, Econs MJ, Peacock M, Imel EA, Thomsen LL, Carpenter TO, Weber T, Brandenburg V, Zoller H

    pmid 32016310

    • established
      Claim: Ferric derisomaltose in heart failure with iron deficiency (IRONMAN RCT) standing
    • resolved

    Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial.

    Kalra PR, Cleland JGF, Petrie MC, Thomson EA, Kalra PA, Squire IB, Ahmed FZ, Al-Mohammad A, Cowburn PJ, Foley PWX, Graham FJ, Japp AG, Lane RE, Lang NN, Ludman AJ, Macdougall IC, Pellicori P, Ray R, Robertson M, Seed A, Ford I, IRONMAN Study Group

    pmid 36347265

A claim's standing is its latest row in an append-only history; a tombstone names the later evidence and the reason. The Graveyard and the Resurrection Yard.

Negative findings

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