In a public-health programme in China covering about 248,000 pregnancies, 400 micrograms of folic acid a day around conception cut neural-tube defects by up to 85% in the northern high-risk region.
established — replicated in humans, or settled by a regulator
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
In a public-health programme in China covering about 248,000 pregnancies, 400 micrograms of folic acid a day around conception cut neural-tube defects by up to 85% in the northern high-risk region. · pmid:10559448
After mandatory folic acid fortification of cereal products in Canada, neural-tube defects fell by 46%, from 1.58 to 0.86 per 1,000 births. · pmid:17625125
Proportion of the 2 claims about Folic acid standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Folic acid yet.
Dose evidence, rung by rung
A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention. · pmid 10559448 · 1999
Reduction in neural-tube defects after folic acid fortification in Canada. · pmid 17625125 · 2007
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
nothing resolved on this rung
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.