GHRP-2

Summary

GHRP-2 (growth hormone-releasing peptide-2) is a ghrelin agonist, acting at the growth hormone secretagogue receptor whose endogenous ligand is ghrelin. · pmid:15507538

Mechanism

In arthritic rats it lowered arthritis scores and serum IL-6, and it prevented endotoxin-induced IL-6 release from macrophages. · pmid:15507538

History

In men with prolonged critical illness, five days of GHRP-2 combined with TRH and GnRH produced greater endocrine and metabolic effects than GHRP-2 alone. · pmid:12030918

Identity

PubChem CID 6918245: Pralmorelin, C45H55N9O6, 818.0 g/mol. · pubchem:6918245

CAS registry number 158861-67-7. · pubchem:6918245

IUPAC name: (2S)-6-amino-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-aminopropanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide. · pubchem:6918245

Where the evidence actually sits

Proportion of the 2 claims about GHRP-2 standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for GHRP-2 yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier

   nothing resolved on this rung

3. Observational evidence · resolved human data at the emerging tier: thin, or contested
   • The combined administration of GH-releasing peptide-2 (GHRP-2), TRH and GnRH to men with prolonged critical illness evokes superior endocrine and metabolic effects compared to treatment with GHRP-2 alone. · pmid 12030918 · 2002
4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work
   • Anti-inflammatory effect of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2) in arthritic rats. · pmid 15507538 · 2005

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.