Glycine crystallizes during freezing: cooling 15% solutions produced beta-glycine, quench-cooling in liquid nitrogen left an amorphous freeze-concentrate, and annealing converted beta- to gamma-glycine.
emerging — human data exists, and it is thin or contested
every claim resolves to its source
All 4 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Glycine crystallizes during freezing: cooling 15% solutions produced beta-glycine, quench-cooling in liquid nitrogen left an amorphous freeze-concentrate, and annealing converted beta- to gamma-glycine. · pmid:11697471
Glycine is a non-essential amino acid that acts in both excitatory and inhibitory neurotransmission, through NMDA-type glutamate receptors and glycine receptors. · pmid:22293292
In healthy volunteers whose sleep was restricted for three nights, 3 g of glycine taken before bed reduced next-day fatigue and improved a psychomotor vigilance test compared with placebo. · pmid:22529837
Mechanism
The pH of the solution before lyophilization, across 1.5 to 10, changed which salt and polymorphic forms of glycine crystallized. · pmid:17245648
In rats, oral glycine raised glycine in plasma and cerebrospinal fluid and lowered core body temperature with increased skin blood flow, a proposed mechanism for its effect on sleep. · pmid:22293292
Proportion of the 4 claims about Glycine standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
4 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Glycine yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
nothing resolved on this rung
Observational evidence· resolved human data at the emerging tier: thin, or contested
The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. · pmid 22529837 · 2012
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
Phase transitions of glycine in frozen aqueous solutions and during freeze-drying. · pmid 11697471 · 2001
Glycine crystallization in frozen and freeze-dried systems: effect of pH and buffer concentration. · pmid 17245648 · 2007
New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep. · pmid 22293292 · 2012
4 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.