Goserelin is a GnRH agonist analogue that reduces testosterone secretion; in a randomized trial in 415 men with locally advanced prostate cancer, adding three years of goserelin to radiotherapy raised five-year survival from 62% to 79%.
established — replicated in humans, or settled by a regulator
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Goserelin is a GnRH agonist analogue that reduces testosterone secretion; in a randomized trial in 415 men with locally advanced prostate cancer, adding three years of goserelin to radiotherapy raised five-year survival from 62% to 79%. · pmid:9233866
In premenopausal women receiving chemotherapy for hormone-receptor-negative breast cancer, adding goserelin lowered ovarian failure at two years (8% against 22%) and more of them later became pregnant. · pmid:25738668
Proportion of the 2 claims about Goserelin standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Goserelin yet.
Dose evidence, rung by rung
A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
Goserelin for ovarian protection during breast-cancer adjuvant chemotherapy. · pmid 25738668 · 2015
Improved survival in patients with locally advanced prostate cancer treated with radiotherapy and goserelin. · pmid 9233866 · 1997
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
nothing resolved on this rung
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.