A meta-analysis of 49 randomized trials in adults on maintenance hemodialysis found that L-carnitine lowered LDL cholesterol and C-reactive protein, but did not confirm earlier findings on hemoglobin or erythropoietin dose.
established — replicated in humans, or settled by a regulator
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
A meta-analysis of 49 randomized trials in adults on maintenance hemodialysis found that L-carnitine lowered LDL cholesterol and C-reactive protein, but did not confirm earlier findings on hemoglobin or erythropoietin dose. · pmid:24368434
A systematic review of 11 studies in healthy people taking oral L-carnitine for 12 to 24 weeks found that it raised muscle carnitine when taken with carbohydrate, and raised fasting plasma trimethylamine-N-oxide (TMAO). · pmid:32958033
Proportion of the 2 claims about L-Carnitine standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for L-Carnitine yet.
Dose evidence, rung by rung
A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
L-Carnitine supplementation for adults with end-stage kidney disease requiring maintenance hemodialysis: a systematic review and meta-analysis. · pmid 24368434 · 2014
Observational evidence· resolved human data at the emerging tier: thin, or contested
The bright and the dark sides of L-carnitine supplementation: a systematic review. · pmid 32958033 · 2020
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
nothing resolved on this rung
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.