Carnosine (beta-alanyl-L-histidine) is a dipeptide discovered in 1900 as an abundant nitrogen compound of meat, found in skeletal muscle and other excitable tissues.
established — replicated in humans, or settled by a regulator
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Carnosine (beta-alanyl-L-histidine) is a dipeptide discovered in 1900 as an abundant nitrogen compound of meat, found in skeletal muscle and other excitable tissues. · pmid:24137022
Mechanism
Its properties include pH buffering, metal-ion chelation, antioxidant capacity and protection against advanced glycation end-products; serum carnosinase degrades it to L-histidine and beta-alanine. · pmid:24137022
At physiological concentrations it trapped peroxyl radicals, supporting a role as an endogenous antioxidant in muscle and brain. · pmid:3362866
Proportion of the 2 claims about L-Carnosine standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for L-Carnosine yet.
Dose evidence, rung by rung
A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
Physiology and pathophysiology of carnosine. · pmid 24137022 · 2013
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain. · pmid 3362866 · 1988
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.