L-Glutathione (reduced)

Summary

Glutathione (gamma-glutamyl-cysteinyl-glycine, GSH) is the most abundant low-molecular-weight thiol in animal cells, made from glutamate, cysteine and glycine by two enzymes in sequence. · pmid:14988435

Mechanism

The glutathione disulfide/glutathione couple is the most abundant redox couple in a cell, and its reduction potential tracks the cell's state, from proliferation to apoptosis. · pmid:11368918

Identity

PubChem CID 124886: Glutathione, C10H17N3O6S, 307.33 g/mol. · pubchem:124886

CAS registry number 70-18-8. · pubchem:124886

IUPAC name: (2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid. · pubchem:124886

Where the evidence actually sits

Proportion of the 2 claims about L-Glutathione (reduced) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for L-Glutathione (reduced) yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier
   • Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. · pmid 11368918 · 2001
   • Glutathione metabolism and its implications for health. · pmid 14988435 · 2004
3. Observational evidence · resolved human data at the emerging tier: thin, or contested

   nothing resolved on this rung

4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work

   nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.