LL-37 is the only cathelicidin-derived antimicrobial peptide found in humans: a 37-residue, amphipathic, helical peptide with a broad spectrum of antimicrobial activity.
established — replicated in humans, or settled by a regulator
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
LL-37 is the only cathelicidin-derived antimicrobial peptide found in humans: a 37-residue, amphipathic, helical peptide with a broad spectrum of antimicrobial activity. · pmid:16716248
Classification
It is expressed in epithelial cells of the skin, gut and airways and in white blood cells, and also regulates inflammation and attracts cells of the adaptive immune system. · pmid:16716248
Mechanism
The human gene encoding it (CAMP) is a direct target of the vitamin D receptor and is strongly induced by 1,25-dihydroxyvitamin D3. · pmid:15985530
Proportion of the 2 claims about LL-37 standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for LL-37 yet.
Dose evidence, rung by rung
A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
LL-37, the only human member of the cathelicidin family of antimicrobial peptides. · pmid 16716248 · 2006
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. · pmid 15985530 · 2005
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.