established — replicated in humans, or settled by a regulator
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Manganese is an essential micronutrient required by enzymes such as arginase and glutamine synthetase, but it is toxic in excess. · pmid:25974698
A review of adults on parenteral nutrition found manganese toxicity after as little as 15 days, with doses in commercial trace-element products often exceeding guideline amounts. · pmid:34753157
Proportion of the 2 claims about Manganese chloride tetrahydrate standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Manganese chloride tetrahydrate yet.
Dose evidence, rung by rung
A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
Manganese Is Essential for Neuronal Health. · pmid 25974698 · 2015
Observational evidence· resolved human data at the emerging tier: thin, or contested
Manganese Toxicity Associated With Total Parenteral Nutrition: A Review. · pmid 34753157 · 2021
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
nothing resolved on this rung
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.