Mechano-growth factor (MGF) names the IGF-IEb mRNA splice variant up-regulated in muscle after injury, and a synthetic peptide matching the 24 most C-terminal residues of that variant.
preclinical — animal, cell or mechanistic work — not yet about people
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Mechano-growth factor (MGF) names the IGF-IEb mRNA splice variant up-regulated in muscle after injury, and a synthetic peptide matching the 24 most C-terminal residues of that variant. · pmid:20130113
Mechanism
The synthetic 24-residue E-domain peptide acted as a pro-migratory factor for human myogenic precursor cells in vitro and in vivo. · pmid:17156777
History
The synthetic peptide promotes cell proliferation and survival, but no analogous peptide product of the IGF-1 gene has been isolated from cells, tissues or biological fluids. · pmid:20130113
Identity
No public registry record is shown for this page: PubChem gave no record that proves it is this substance.
Where the evidence actually sits
Preclinical only100%
Proportion of the 2 claims about Mechano Growth Factor standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Mechano Growth Factor yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
nothing resolved on this rung
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
A new pro-migratory activity on human myogenic precursor cells for a synthetic peptide within the E domain of the mechano growth factor. · pmid 17156777 · 2007
Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration. · pmid 20130113 · 2010
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.