established — replicated in humans, or settled by a regulator
every claim resolves to its source
All 3 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Pentosan polysulfate is a sulfated oligosaccharide, not a peptide. · pmid:2465736
History
In a 1990 double-blind multicentre trial in interstitial cystitis, overall improvement above 25% was reported by 28% of 110 patients on pentosan polysulfate sodium against 13% on placebo. · pmid:1693797
Chronic exposure has been associated with a distinctive pigmentary maculopathy; the first case series described six patients with a median exposure of 186 months. · pmid:29801663
Identity
No public registry record is shown for this page: PubChem gave no record that proves it is this substance.
Where the evidence actually sits
Established33%
Emerging33%
Preclinical only33%
Proportion of the 3 claims about Pentosan Polysulfate Sodium standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
3 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Pentosan Polysulfate Sodium yet.
Dose evidence, rung by rung
A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
Pentosan polysulfate sodium for therapy of interstitial cystitis. A double-blind placebo-controlled clinical study. · pmid 1693797 · 1990
Observational evidence· resolved human data at the emerging tier: thin, or contested
Pigmentary Maculopathy Associated with Chronic Exposure to Pentosan Polysulfate Sodium. · pmid 29801663 · 2018
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
Pentosan polysulfate, a sulfated oligosaccharide, is a potent and selective anti-HIV agent in vitro. · pmid 2465736 · 1988
3 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.