Peptide Atlas · Buffer system

Phosphate buffer

Sodium phosphate buffers can acidify sharply on freezing: crystallization of the disodium salt as the dodecahydrate caused abrupt pH drops after ice began to form.

preclinical

provisional
2 citations
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What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- preclinical
  Claim: pH changes during freezing of sodium phosphate buffers standing
- resolved
Effect of initial buffer composition on pH changes during far-from-equilibrium freezing of sodium phosphate buffer solutions.
Gómez G, Pikal MJ, Rodríguez-Hornedo N
pmid 11336359
- preclinical
  Claim: Mitigating phosphate acidification with Good's buffers standing
- resolved
Making good's buffers good for freezing: The acidity changes and their elimination via mixing with sodium phosphate.
Veselý L, Susrisweta B, Heger D
pmid 33271311

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