Pinealon

Summary

Pinealon is the synthetic tripeptide Glu-Asp-Arg. · pmid:21978084

Mechanism

It dose-dependently restricted the accumulation of reactive oxygen species in cerebellar granule cells, neutrophils and PC12 cells under oxidative stress, and decreased necrotic cell death. · pmid:21978084

Identity

PubChem CID 10273502: Glu-Asp-Arg, C15H26N6O8, 418.40 g/mol. · pubchem:10273502

CAS registry number 175175-23-2. · pubchem:10273502

IUPAC name: (4S)-4-amino-5-[[(2S)-3-carboxy-1-[[(1S)-1-carboxy-4-(diaminomethylideneamino)butyl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid. · pubchem:10273502

Where the evidence actually sits

Proportion of the 1 claim about Pinealon standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

1 resolved citation, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Pinealon yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier

   nothing resolved on this rung

3. Observational evidence · resolved human data at the emerging tier: thin, or contested

   nothing resolved on this rung

4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work
   • Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes. · pmid 21978084 · 2011

1 resolved citation, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.