Peptide Atlas · Peptide

Semaglutide

Semaglutide is a glucagon-like peptide-1 analogue with two amino acid substitutions (Aib8, Arg34) and a fatty-acid derivatization at lysine 26, designed for high albumin affinity and once-weekly dosing.

established

provisional
PubChem 56843331
3 citations
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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 3 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

created page created as 'Semaglutide' · 2026-09-27 04:00 · somebody
kind set kind set to peptide: palette r1 · 2026-09-27 04:00 · somebody
fact added identity: PubChem CID 56843331: Semaglutide, C187H291N45O59, 4114 g/mol. · 2026-09-27 04:00 · somebody
fact added identity: CAS registry number 910463-68-2. · 2026-09-27 04:00 · somebody
fact added summary: Semaglutide is a glucagon-like peptide-1 analogue with two amino acid substitutions (Aib8, Arg34) and a fatty-acid deriv · 2026-09-27 04:00 · somebody
fact added history: In SUSTAIN-6, 3,297 patients with type 2 diabetes had fewer cardiovascular deaths, non-fatal heart attacks or non-fatal · 2026-09-27 04:00 · somebody
fact added history: In the 68-week STEP 1 trial of 1,961 adults with overweight or obesity, mean body weight fell by 14.9% on semaglutide 2. · 2026-09-27 04:00 · somebody
citation added pmid 26308095 cited as preclinical: Discovery of the once-weekly GLP-1 analogue semaglutide · 2026-09-27 04:00 · somebody
citation added pmid 27633186 cited as established: SUSTAIN-6 cardiovascular outcomes trial · 2026-09-27 04:00 · somebody
citation added pmid 33567185 cited as established: STEP 1 trial in adults with overweight or obesity · 2026-09-27 04:00 · somebody

Negative findings

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