A survey of US complementary-medicine practitioners found high-dose intravenous vitamin C given to thousands of patients a year, mostly with minor side effects; serious events, including two deaths, were published in patients with known risks such as kidney impairment or G6PD deficiency.
established — replicated in humans, or settled by a regulator
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
A survey of US complementary-medicine practitioners found high-dose intravenous vitamin C given to thousands of patients a year, mostly with minor side effects; serious events, including two deaths, were published in patients with known risks such as kidney impairment or G6PD deficiency. · pmid:20628650
Mechanism
Only intravenous vitamin C reaches high plasma concentrations: 1.25 g gave peak levels of about 885 micromol/L intravenously against about 135 micromol/L by mouth. · pmid:15068981
Proportion of the 2 claims about Sodium ascorbate (Vitamin C salt) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Sodium ascorbate (Vitamin C salt) yet.
Dose evidence, rung by rung
A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
Vitamin C pharmacokinetics: implications for oral and intravenous use. · pmid 15068981 · 2004
Observational evidence· resolved human data at the emerging tier: thin, or contested
Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects. · pmid 20628650 · 2010
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
nothing resolved on this rung
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.