When sodium phosphate buffers freeze, the disodium salt can crystallize as the dodecahydrate, causing abrupt pH drops shortly after ice forms, between -0.5 and -4.0 C.
fact added summary: When sodium phosphate buffers freeze, the disodium salt can crystallize as the dodecahydrate, causing abrupt pH drops sh · 2026-09-27 04:00 · somebody
citation added pmid 11336359 cited as preclinical: pH changes during freezing of sodium phosphate buffers · 2026-09-27 04:00 · somebody
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