Succinate buffer can crystallize in frozen solutions, shifting the pH of the freeze-concentrate; at an initial pH of 6.0, glycine and mannitol stayed amorphous and inhibited that crystallization.
fact added summary: Succinate buffer can crystallize in frozen solutions, shifting the pH of the freeze-concentrate; at an initial pH of 6.0 · 2026-09-27 04:00 · somebody
citation added pmid 20927571 cited as preclinical: Succinate buffer crystallization and the pH shift in frozen solutions · 2026-09-27 04:00 · somebody
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