Thymosin alpha 1 is a heat-stable, highly acidic polypeptide of 28 amino acids, isolated from calf thymus as one of the peptides of thymosin fraction 5.
established — replicated in humans, or settled by a regulator
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Thymosin alpha 1 is a heat-stable, highly acidic polypeptide of 28 amino acids, isolated from calf thymus as one of the peptides of thymosin fraction 5. · pmid:265536
Mechanism
It induced functional maturation and interleukin-12 production in fungus-pulsed dendritic cells through Toll-like receptor signalling, and protected transplanted mice from aspergillosis. · pmid:14982877
Proportion of the 2 claims about Thymosin Alpha-1 standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Thymosin Alpha-1 yet.
Dose evidence, rung by rung
A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide. · pmid 265536 · 1977
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through toll-like receptor signaling. · pmid 14982877 · 2004
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.