Thymulin

Summary

Thymulin is a thymic hormone that needs zinc for its activity; serum thymulin activity fell in mild human zinc deficiency and was restored by zinc supplementation, making it a sensitive indicator of zinc status. · pmid:3262625

Mechanism

Interleukin 1 stimulated human thymic epithelial cells to take up zinc and to secrete thymulin, and the zinc-thymulin complex activated nuclear protein kinase C in lymphocytes. · pmid:1502195

Identity

PubChem CID 3085284: Nonathymulin, C33H54N12O15, 858.9 g/mol. · pubchem:3085284

CAS registry number 63958-90-7. · pubchem:3085284

IUPAC name: (2S)-4-amino-2-[[(2S)-2-[[2-[[2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoic acid. · pubchem:3085284

Where the evidence actually sits

Proportion of the 2 claims about Thymulin standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Thymulin yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier

   nothing resolved on this rung

3. Observational evidence · resolved human data at the emerging tier: thin, or contested
   • Serum thymulin in human zinc deficiency. · pmid 3262625 · 1988
4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work
   • Interleukin 1 regulates secretion of zinc-thymulin by human thymic epithelial cells and its action on T-lymphocyte proliferation and nuclear protein kinase C. · pmid 1502195 · 1992

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.