The tripeptide Lys-Glu-Asp stimulated proliferation and inhibited apoptosis in organotypic cultures of neuroimmunoendocrine cells, with a stronger effect in cultures from old animals.
preclinical — animal, cell or mechanistic work — not yet about people
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
The tripeptide Lys-Glu-Asp stimulated proliferation and inhibited apoptosis in organotypic cultures of neuroimmunoendocrine cells, with a stronger effect in cultures from old animals. · pmid:22977872
Mechanism
A 2022 review lists the KED tripeptide among vasoprotective peptides that regulate molecules of the senescence-associated secretory phenotype in cardiovascular cells. · pmid:36611900
Proportion of the 2 claims about Vesugen standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Vesugen yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
nothing resolved on this rung
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
Effect of tripeptide Lys-Glu-Asp on physiological activity of neuroimmunoendocrine system cells. · pmid 22977872 · 2012
Senescence-Associated Secretory Phenotype of Cardiovascular System Cells and Inflammaging: Perspectives of Peptide Regulation. · pmid 36611900 · 2022
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.