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Research

Acetate salt — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Despite most early peptide research using trifluoroacetate salts, the great majority of therapeutic peptides are marketed as hydrochloride or acetate salts. · pmid:40365687

Mechanism

Acetate, hydrochloride and trifluoroacetate salts of the same antimicrobial peptides differed in activity and toxicity, without a consistent pattern across peptides. · pmid:29307075

Identity

Counterion: Acetic Acid, C2H4O2, 60.05 g/mol (PubChem CID 176). · pubchem:176

IUPAC name: acetic acid. · pubchem:176

Where the evidence actually sits

Established50%
Preclinical only50%

Proportion of the 2 claims about Acetate salt standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Counter-ion effect on antistaphylococcal activity and cytotoxicity of selected antimicrobial peptides. (2018) · preclinicalImpact of counterion and salt form on the properties of long-acting injectable peptide hydrogels for drug delivery. (2025) · established20182025

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Acetate salt yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier
    • Impact of counterion and salt form on the properties of long-acting injectable peptide hydrogels for drug delivery. · pmid 40365687 · 2025
  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work
    • Counter-ion effect on antistaphylococcal activity and cytotoxicity of selected antimicrobial peptides. · pmid 29307075 · 2018

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.