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Research

Alanyl-Glutamine (Dipeptiven) — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

L-alanyl-L-glutamine is a dipeptide used to deliver glutamine in intravenous nutrition; after major abdominal surgery, parenteral nutrition enriched with it improved nitrogen balance and lymphocyte recovery in a randomized, double-blind study of 28 patients. · pmid:9488531

In a French multicenter double-blind trial in 114 intensive-care patients, alanyl-glutamine-supplemented parenteral nutrition lowered complicated outcomes (41% against 61%), mainly infections and pneumonia, and hyperglycemia, without changing early deaths or 6-month survival. · pmid:16505644

Identity

PubChem CID 123935: L-Alanyl-L-Glutamine, C8H15N3O4, 217.22 g/mol. · pubchem:123935

CAS registry number 39537-23-0. · pubchem:123935

IUPAC name: (2S)-5-amino-2-[[(2S)-2-aminopropanoyl]amino]-5-oxopentanoic acid. · pubchem:123935

Where the evidence actually sits

Emerging100%

Proportion of the 2 claims about Alanyl-Glutamine (Dipeptiven) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Total parenteral nutrition with glutamine dipeptide after major abdominal surgery: a randomized, double-blind, controlled study. (1998) · emergingL-alanyl-L-glutamine dipeptide-supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: the French controlled, randomized, double-blind, multicenter study. (2006) · emerging19982006

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Alanyl-Glutamine (Dipeptiven) yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier

    nothing resolved on this rung

  3. Observational evidence · resolved human data at the emerging tier: thin, or contested
    • L-alanyl-L-glutamine dipeptide-supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: the French controlled, randomized, double-blind, multicenter study. · pmid 16505644 · 2006
    • Total parenteral nutrition with glutamine dipeptide after major abdominal surgery: a randomized, double-blind, controlled study. · pmid 9488531 · 1998
  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.