PepJunkie Home of the Peptonauts
More
HomeThe PulseAtlasDiscussHunter-GathererResearchProfileSearch

Research

AOD-9604 — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

AOD9604 is a synthetic analogue of the lipolytic domain of human growth hormone, taken from the hormone's C-terminus. · pmid:11146367

Mechanism

In mice its lipolytic action was not mediated directly through the beta-3 adrenergic receptor, although it raised that receptor's expression in obese animals. · pmid:11713213

History

In obese Zucker rats, 19 days of oral AOD9604 cut body weight gain by more than half, and unlike intact growth hormone it did not impair insulin sensitivity. · pmid:11146367

Identity

PubChem CID 71300630: Aod-9604, C78H123N23O23S2, 1815.1 g/mol. · pubchem:71300630

CAS registry number 221231-10-3. · pubchem:71300630

Where the evidence actually sits

Preclinical only100%

Proportion of the 2 claims about AOD-9604 standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. (2000) · preclinicalThe effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. (2001) · preclinical20002001

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for AOD-9604 yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier

    nothing resolved on this rung

  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work
    • Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. · pmid 11146367 · 2000
    • The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. · pmid 11713213 · 2001

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.