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Research

Ascorbic acid — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

In the LOVIT trial of 872 adults with sepsis on vasopressors, intravenous vitamin C raised the risk of death or persistent organ dysfunction at 28 days compared with placebo (44.5% against 38.5%). · pmid:35704292

Mechanism

Plasma vitamin C is tightly controlled when it is taken by mouth: 1.25 g orally gave peak plasma levels of about 135 micromol/L against about 885 micromol/L intravenously, and modelling predicted a 60-fold gap at the highest doses. · pmid:15068981

Identity

PubChem CID 54670067: L-Ascorbic Acid, C6H8O6, 176.12 g/mol. · pubchem:54670067

CAS registry number 50-81-7. · pubchem:54670067

IUPAC name: (2R)-2-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2H-furan-5-one. · pubchem:54670067

Where the evidence actually sits

Established100%

Proportion of the 2 claims about Ascorbic acid standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Vitamin C pharmacokinetics: implications for oral and intravenous use. (2004) · establishedIntravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit. (2022) · established20042022

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Ascorbic acid yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier
    • Vitamin C pharmacokinetics: implications for oral and intravenous use. · pmid 15068981 · 2004
    • Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit. · pmid 35704292 · 2022
  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.