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Bacteriostatic water for injection — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Bacteriostatic water for injection is sterile water for injection containing one or more antimicrobial agents; the USP monograph allows pH 4.5 to 7.0, and it contains no buffering reagents, so it has very low ionic strength and no buffering capacity. · pmid:36870668

History

Benzyl alcohol, used as its preservative, was the subject of 1982 reports of fatal poisoning in a neonatal intensive care unit. · pmid:6123006

Identity

No public registry record is shown for this page: a mixture (water with a preservative), not one compound.

Where the evidence actually sits

Established100%

Proportion of the 4 claims about Bacteriostatic water for injection standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Fatal benzyl alcohol poisoning in a neonatal intensive care unit. (1982) · establishedThe gasping syndrome and benzyl alcohol poisoning. (1982) · establishedNeurotoxicity of bacteriostatic water. (1983) · establishedCritical Aspects of pH Measurement for Bacteriostatic Water for Injection. (2023) · established19822023

4 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Bacteriostatic water for injection yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier
    • Critical Aspects of pH Measurement for Bacteriostatic Water for Injection. · pmid 36870668 · 2023
    • Fatal benzyl alcohol poisoning in a neonatal intensive care unit. · pmid 6123006 · 1982
    • Neurotoxicity of bacteriostatic water. · pmid 6687625 · 1983
    • The gasping syndrome and benzyl alcohol poisoning. · pmid 7133084 · 1982
  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

4 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.