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Research

Biotin — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

In a randomized, double-blind trial in 154 people with progressive multiple sclerosis, high-dose biotin (MD1003, 100 mg three times daily) reversed disability in 12.6% against none on placebo. · pmid:27589059

Identity

PubChem CID 171548: Biotin, C10H16N2O3S, 244.31 g/mol. · pubchem:171548

CAS registry number 58-85-5. · pubchem:171548

IUPAC name: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid. · pubchem:171548

Where the evidence actually sits

Emerging100%

Proportion of the 1 claim about Biotin standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, placebo-controlled study. (2016) · emerging20162016

1 resolved citation, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Biotin yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier

    nothing resolved on this rung

  3. Observational evidence · resolved human data at the emerging tier: thin, or contested
    • MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, placebo-controlled study. · pmid 27589059 · 2016
  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

1 resolved citation, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.