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Research

Citric Acid — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Citrate is a common buffer in injectable biologics; a systematic review found that five of seven direct comparisons reported less injection-site pain with citrate-free formulations. · pmid:36043729

Identity

PubChem CID 22230: 2-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1), C6H10O8, 210.14 g/mol. · pubchem:22230

CAS registry number 5949-29-1. · pubchem:22230

IUPAC name: 2-hydroxypropane-1,2,3-tricarboxylic acid;hydrate. · pubchem:22230

Where the evidence actually sits

Emerging100%

Proportion of the 1 claim about Citric Acid standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

A Systematic Literature Review of Injection Site Pain Perception in Adult Patients Treated with Citrate-Free and Citrate-Containing Biologic Agents. (2023) · emerging20232023

1 resolved citation, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Citric Acid yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier

    nothing resolved on this rung

  3. Observational evidence · resolved human data at the emerging tier: thin, or contested
    • A Systematic Literature Review of Injection Site Pain Perception in Adult Patients Treated with Citrate-Free and Citrate-Containing Biologic Agents. · pmid 36043729 · 2023
  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

1 resolved citation, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.