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Research

Creatine phosphate (phosphocreatine) — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

In a randomized, double-blind pilot trial in 120 high-risk valve-surgery patients, intravenous and cardioplegic phosphocreatine did not lower peak troponin I after surgery compared with saline, nor change creatinine, inotrope use or other secondary outcomes. · pmid:38030971

Mechanism

Phosphocreatine is the heart's high-energy phosphate reserve; in 39 people with dilated cardiomyopathy, a low myocardial phosphocreatine-to-ATP ratio measured by phosphorus MR spectroscopy predicted higher mortality over 2.5 years. · pmid:9337189

Identity

PubChem CID 9548602: Phosphocreatine, C4H10N3O5P, 211.11 g/mol. · pubchem:9548602

CAS registry number 67-07-2. · pubchem:9548602

IUPAC name: 2-[methyl-[(E)-N'-phosphonocarbamimidoyl]amino]acetic acid. · pubchem:9548602

Where the evidence actually sits

Emerging100%

Proportion of the 2 claims about Creatine phosphate (phosphocreatine) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy. (1997) · emergingMyocardial protection with phosphocreatine in high-risk cardiac surgery patients: a randomized trial. (2023) · emerging19972023

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Creatine phosphate (phosphocreatine) yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier

    nothing resolved on this rung

  3. Observational evidence · resolved human data at the emerging tier: thin, or contested
    • Myocardial protection with phosphocreatine in high-risk cardiac surgery patients: a randomized trial. · pmid 38030971 · 2023
    • Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy. · pmid 9337189 · 1997
  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.