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Research

Cyanocobalamin — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

In a dose-finding trial in 120 older people with mild vitamin B12 deficiency, oral cyanocobalamin normalised the deficiency marker methylmalonic acid only at about 650 to 1,000 micrograms a day, over 200 times the recommended dietary allowance. · pmid:15911731

In ten patients with pernicious anemia, oral crystalline cyanocobalamin (1,000 micrograms a day for three months) raised serum cobalamin and hemoglobin in most of them. · pmid:24672108

Identity

PubChem CID 165339223: Vitamin B12, C63H88CoN14O14P, 1355.4 g/mol. · pubchem:165339223

CAS registry number 68-19-9. · pubchem:165339223

Where the evidence actually sits

Established50%
Emerging50%

Proportion of the 2 claims about Cyanocobalamin standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial. (2005) · establishedEffects of oral crystalline cyanocobalamin 1000 μg/d in the treatment of pernicious anemia: An open-label, prospective study in Ten Patients. (2005) · emerging20052005

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Cyanocobalamin yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier
    • Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial. · pmid 15911731 · 2005
  3. Observational evidence · resolved human data at the emerging tier: thin, or contested
    • Effects of oral crystalline cyanocobalamin 1000 μg/d in the treatment of pernicious anemia: An open-label, prospective study in Ten Patients. · pmid 24672108 · 2005
  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.