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Research

Dexpanthenol — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Dexpanthenol is the stable alcohol analogue of pantothenic acid, a component of coenzyme A; applied to the skin it acts as a moisturiser, reduces water loss and has been reported to speed wound re-epithelialisation. · pmid:12113650

Mechanism

In a placebo-controlled study of wounded human skin, topical dexpanthenol changed the expression of wound-healing genes such as IL-6, IL-1-beta and CXCL1. · pmid:22759998

Identity

PubChem CID 131204: Dexpanthenol, C9H19NO4, 205.25 g/mol. · pubchem:131204

CAS registry number 81-13-0. · pubchem:131204

IUPAC name: (2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide. · pubchem:131204

Where the evidence actually sits

Emerging100%

Proportion of the 2 claims about Dexpanthenol standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Topical use of dexpanthenol in skin disorders. (2002) · emergingDexpanthenol modulates gene expression in skin wound healing in vivo. (2012) · emerging20022012

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Dexpanthenol yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier

    nothing resolved on this rung

  3. Observational evidence · resolved human data at the emerging tier: thin, or contested
    • Topical use of dexpanthenol in skin disorders. · pmid 12113650 · 2002
    • Dexpanthenol modulates gene expression in skin wound healing in vivo. · pmid 22759998 · 2012
  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.