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Research

Dimethyl sulfoxide — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Dimethyl sulfoxide (DMSO) has been the cryoprotectant of choice for most animal cell systems since the early history of cryopreservation, used in many thousands of cell transplants. · pmid:32342730

Dimethyl sulfoxide (DMSO) has been the cryoprotectant of choice for most animal cell systems since the early days of cryopreservation, used for stored bone marrow and blood cells in many thousands of transplants, while its toxicity in patients remains debated. · pmid:32342730

History

Its effects on cell biology and apparent toxicity in patients remain debated, driving a search for less cytotoxic cryoprotectants. · pmid:32342730

Identity

PubChem CID 679: Dimethyl Sulfoxide, C2H6OS, 78.14 g/mol. · pubchem:679

CAS registry number 67-68-5. · pubchem:679

IUPAC name: methylsulfinylmethane. · pubchem:679

Where the evidence actually sits

Established100%

Proportion of the 2 claims about Dimethyl sulfoxide standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Dimethyl sulfoxide: a central player since the dawn of cryobiology, is efficacy balanced by toxicity? (2020) · establishedDimethyl sulfoxide: a central player since the dawn of cryobiology, is efficacy balanced by toxicity? (2020) · established20202020

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Dimethyl sulfoxide yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier
    • Dimethyl sulfoxide: a central player since the dawn of cryobiology, is efficacy balanced by toxicity? · pmid 32342730 · 2020
    • Dimethyl sulfoxide: a central player since the dawn of cryobiology, is efficacy balanced by toxicity? · pmid 32342730 · 2020
  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.