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Research

DL-alpha-Tocopherol (free Vitamin E) — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Using deuterium-labelled forms, natural (RRR) vitamin E reached about twice the plasma and tissue availability of synthetic (all-rac) vitamin E in humans. · pmid:9537614

In a three-year randomized trial in healthy adults with raised LDL cholesterol, DL-alpha-tocopherol (400 IU a day) reduced LDL oxidation but did not slow carotid artery wall thickening. · pmid:12234947

Identity

PubChem CID 2116: DL-alpha-Tocopherol, C29H50O2, 430.7 g/mol. · pubchem:2116

CAS registry number 10191-41-0. · pubchem:2116

IUPAC name: 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-ol. · pubchem:2116

Where the evidence actually sits

Established50%
Emerging50%

Proportion of the 2 claims about DL-alpha-Tocopherol (free Vitamin E) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Human plasma and tissue alpha-tocopherol concentrations in response to supplementation with deuterated natural and synthetic vitamin E. (1998) · emergingAlpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis: the Vitamin E Atherosclerosis Prevention Study (VEAPS). (2002) · established19982002

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for DL-alpha-Tocopherol (free Vitamin E) yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier
    • Alpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis: the Vitamin E Atherosclerosis Prevention Study (VEAPS). · pmid 12234947 · 2002
  3. Observational evidence · resolved human data at the emerging tier: thin, or contested
    • Human plasma and tissue alpha-tocopherol concentrations in response to supplementation with deuterated natural and synthetic vitamin E. · pmid 9537614 · 1998
  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.