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Research

Epitalon — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Epitalon (Epithalon) is the tetrapeptide Ala-Glu-Asp-Gly (AEDG), synthesized on the basis of the amino acid composition of epithalamin, a bovine pineal gland extract. · pmid:40141333

Mechanism

Added to telomerase-negative human fetal fibroblasts, it induced expression of the telomerase catalytic subunit, telomerase activity and telomere elongation. · pmid:12937682

History

Given monthly to female CBA mice from six months of age until natural death, the tetrapeptide increased mean survival by 5.3% and lowered spontaneous tumour incidence. · pmid:11163623

A 2025 review notes that physico-chemical and structural studies of the peptide remain limited and that it is uncertain whether its reported mechanisms are its only ones. · pmid:40141333

Identity

PubChem CID 219042: Epitalon, C14H22N4O9, 390.35 g/mol. · pubchem:219042

CAS registry number 307297-39-8. · pubchem:219042

IUPAC name: (4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid. · pubchem:219042

Where the evidence actually sits

Preclinical only100%

Proportion of the 3 claims about Epitalon standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice. (2001) · preclinicalEpithalon peptide induces telomerase activity and telomere elongation in human somatic cells. (2003) · preclinicalOverview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties. (2025) · preclinical20012025

3 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Epitalon yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier

    nothing resolved on this rung

  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work
    • Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice. · pmid 11163623 · 2001
    • Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. · pmid 12937682 · 2003
    • Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties. · pmid 40141333 · 2025

3 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.