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Research

FGL — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Mechanism

FGL is a synthetic peptide from the second fibronectin type III module of the neural cell adhesion molecule (NCAM) that binds and activates the fibroblast growth factor receptor, inducing neurite outgrowth and neuronal survival in cultured rat neurons. · pmid:15525346

FGL protected rat hippocampal neurons from oxygen-glucose deprivation, and a single injection before transient global ischemia protected hippocampal neurons in gerbils. · pmid:16197499

Identity

PubChem CID 16200289: FGL peptide, C71H116N20O25, 1649.8 g/mol. · pubchem:16200289

CAS registry number 499993-62-3. · pubchem:16200289

Where the evidence actually sits

Preclinical only100%

Proportion of the 2 claims about FGL standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

An NCAM-derived FGF-receptor agonist, the FGL-peptide, induces neurite outgrowth and neuronal survival in primary rat neurons. (2004) · preclinicalA synthetic NCAM-derived peptide, FGL, protects hippocampal neurons from ischemic insult both in vitro and in vivo. (2005) · preclinical20042005

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for FGL yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier

    nothing resolved on this rung

  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work
    • An NCAM-derived FGF-receptor agonist, the FGL-peptide, induces neurite outgrowth and neuronal survival in primary rat neurons. · pmid 15525346 · 2004
    • A synthetic NCAM-derived peptide, FGL, protects hippocampal neurons from ischemic insult both in vitro and in vivo. · pmid 16197499 · 2005

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.