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Research

GLP-1 — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Glucagon-like peptide 1 is a 30-amino-acid hormone made in the intestinal L-cells by processing of proglucagon and released in response to meals. · pmid:17928588

Mechanism

Its main actions are to stimulate insulin secretion and inhibit glucagon secretion, limiting glucose rises after meals; it also slows gastrointestinal motility. · pmid:17928588

It is inactivated extremely rapidly by dipeptidyl peptidase IV, even before leaving the gut. · pmid:17928588

Identity

PubChem CID 16133831: Glucagon-Like Peptide 1, C149H226N40O45, 3297.6 g/mol. · pubchem:16133831

Where the evidence actually sits

Established100%

Proportion of the 1 claim about GLP-1 standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

The physiology of glucagon-like peptide 1. (2007) · established20072007

1 resolved citation, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for GLP-1 yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier
    • The physiology of glucagon-like peptide 1. · pmid 17928588 · 2007
  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

1 resolved citation, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.