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Research

Glycerol — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Glycerol is a cosolvent that stabilizes proteins in solution: seven proteins studied in glycerol-water mixtures were preferentially hydrated, which minimizes glycerol contact and favours the native structure. · pmid:7295639

Mechanism

It shifts proteins toward more compact states and inhibits aggregation during refolding, largely through electrostatic interactions that orient glycerol at the protein surface. · pmid:19817484

Identity

CAS registry number 56-81-5. · pubchem:753

PubChem CID 753: Glycerol, C3H8O3, 92.09 g/mol. · pubchem:753

IUPAC name: propane-1,2,3-triol. · pubchem:753

Where the evidence actually sits

Preclinical only100%

Proportion of the 2 claims about Glycerol standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Mechanism of protein stabilization by glycerol: preferential hydration in glycerol-water mixtures. (1981) · preclinicalMechanisms of protein stabilization and prevention of protein aggregation by glycerol. (2009) · preclinical19812009

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Glycerol yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier

    nothing resolved on this rung

  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work
    • Mechanisms of protein stabilization and prevention of protein aggregation by glycerol. · pmid 19817484 · 2009
    • Mechanism of protein stabilization by glycerol: preferential hydration in glycerol-water mixtures. · pmid 7295639 · 1981

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.