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Research

Glycine — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Glycine crystallizes during freezing: cooling 15% solutions produced beta-glycine, quench-cooling in liquid nitrogen left an amorphous freeze-concentrate, and annealing converted beta- to gamma-glycine. · pmid:11697471

Glycine is a non-essential amino acid that acts in both excitatory and inhibitory neurotransmission, through NMDA-type glutamate receptors and glycine receptors. · pmid:22293292

In healthy volunteers whose sleep was restricted for three nights, 3 g of glycine taken before bed reduced next-day fatigue and improved a psychomotor vigilance test compared with placebo. · pmid:22529837

Mechanism

The pH of the solution before lyophilization, across 1.5 to 10, changed which salt and polymorphic forms of glycine crystallized. · pmid:17245648

In rats, oral glycine raised glycine in plasma and cerebrospinal fluid and lowered core body temperature with increased skin blood flow, a proposed mechanism for its effect on sleep. · pmid:22293292

Identity

PubChem CID 750: Glycine, C2H5NO2, 75.07 g/mol. · pubchem:750

CAS registry number 56-40-6. · pubchem:750

IUPAC name: 2-aminoacetic acid. · pubchem:750

Where the evidence actually sits

Emerging25%
Preclinical only75%

Proportion of the 4 claims about Glycine standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Phase transitions of glycine in frozen aqueous solutions and during freeze-drying. (2001) · preclinicalGlycine crystallization in frozen and freeze-dried systems: effect of pH and buffer concentration. (2007) · preclinicalNew therapeutic strategy for amino acid medicine: glycine improves the quality of sleep. (2012) · preclinicalThe effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. (2012) · emerging20012012

4 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Glycine yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier

    nothing resolved on this rung

  3. Observational evidence · resolved human data at the emerging tier: thin, or contested
    • The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. · pmid 22529837 · 2012
  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work
    • Phase transitions of glycine in frozen aqueous solutions and during freeze-drying. · pmid 11697471 · 2001
    • Glycine crystallization in frozen and freeze-dried systems: effect of pH and buffer concentration. · pmid 17245648 · 2007
    • New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep. · pmid 22293292 · 2012

4 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.