Research
Hexarelin — living evidence map
The Atlas page holds the claims; this is how its evidence evolved.
Summary
Hexarelin is a synthetic growth hormone-releasing hexapeptide; given intravenously to healthy volunteers it released about twice as much growth hormone as the same dose of growth hormone-releasing hormone. · pmid:8126144
Mechanism
In hypophysectomized rats it protected the heart from ischemia-reperfusion damage, an action the authors concluded is not mediated by growth hormone but likely by specific cardiac receptors. · pmid:10465272
Identity
PubChem CID 6918297: Examorelin, C47H58N12O6, 887.0 g/mol. · pubchem:6918297
CAS registry number 140703-51-1, 208251-52-9. · pubchem:6918297
IUPAC name: (2S)-6-amino-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(2-methyl-1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide. · pubchem:6918297
Where the evidence actually sits
Proportion of the 2 claims about Hexarelin standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Hexarelin yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
- Approved-label dose · a resolved regulatory document names a labelled dose
nothing resolved on this rung
- Studied human doses · resolved human studies at the established tier
nothing resolved on this rung
- Observational evidence · resolved human data at the emerging tier: thin, or contested
- Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, after intravenous, subcutaneous, intranasal, and oral administration in man. · pmid 8126144 · 1994
- Community-reported protocols · protocol propositions from distinct members, counted once per human
nothing resolved on this rung
- Preclinical evidence · resolved animal, cell or mechanistic work
- Growth hormone-independent cardioprotective effects of hexarelin in the rat. · pmid 10465272 · 1999
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.