Research
Humanin — living evidence map
The Atlas page holds the claims; this is how its evidence evolved.
Summary
Humanin is an anti-apoptotic peptide of 24 amino acids; an identical open reading frame exists in the mitochondrial genome, and the mitochondrial version also binds and suppresses the cell-death protein Bax. · pmid:12732850
Classification
It is described as the first small peptide of a putative set of mitochondrial-derived peptides, with strong cytoprotective actions in stress and disease models. · pmid:23402768
Mechanism
It prevents Bax from moving from the cytosol to mitochondria and suppresses cytochrome c release. · pmid:12732850
Identity
PubChem CID 16131438: Humanin, C119H204N34O32S2, 2687.2 g/mol. · pubchem:16131438
CAS registry number 330936-69-1. · pubchem:16131438
Where the evidence actually sits
Proportion of the 2 claims about Humanin standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Humanin yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
- Approved-label dose · a resolved regulatory document names a labelled dose
nothing resolved on this rung
- Studied human doses · resolved human studies at the established tier
nothing resolved on this rung
- Observational evidence · resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
- Community-reported protocols · protocol propositions from distinct members, counted once per human
nothing resolved on this rung
- Preclinical evidence · resolved animal, cell or mechanistic work
- Humanin peptide suppresses apoptosis by interfering with Bax activation. · pmid 12732850 · 2003
- Humanin: a harbinger of mitochondrial-derived peptides? · pmid 23402768 · 2013
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.